Event Title First Global Alliance for Research on Avian Diseases (GARAD) Conference
Session Title Unknown
Event Date & Time On Wed, 01 Jul 2015 at 09:00:00 - 09:25:00
Venue Edmond J. Safra Lecture Theatre
Abstract Title Bacterial infections of poultry - new approaches to vaccination and other methods of infection control
Authors Paul Barrow
Affiliations School of Veterinary Medicine and Science University of Nottingham
Abstract Content

Much of my work during the last 30 years has involved exploring novel approaches to controlling bacterial and other infections. Vaccination using live, attenuated or inactivated vaccines, has been the backbone to immune protection. However, there remains scope for improving both. Most inactivated vaccines involve culturing the target pathogen in a variety of culture media but the antigens that they express may not be those which are expressed in vivo. There are ways that this can be improved. Live vaccines, administered orally not only stimulate adaptive immunity but generate a rapid non-specific immunity through stimulation of innate mechanisms. In addition they can colonise the alimentary tract providing a strong protective barrier through a microbial exclusion effect. Bacterial viruses (bacteriophages), administered carefully, can be used to control systemic and enteric infections and can also be used to decontaminate carcass surfaces. The parasitic bacterium Bdellovibrio, can also be used in this way. If bacterial viruses can be used to control bacterial infections there may be an opportunity to use parasite viruses in the same way. There remains considerable potential for a more imaginative approach to infection control.